Van Helsing is set in the near future, where vampires have risen and taken control. Vanessa Van Helsing, a descendant of Abraham Van Helsing, awakens from a three-year coma after her supposed death to find herself in a post-apocalyptic world. She is humanity's last hope, as her unique blood composition gives her the ability to turn vampires human. With this secret weapon, Vanessa becomes a prime target for the vampires. She has been protected by a Marine ordered to keep her safe, and the doctor who saved her, so she can lead a resistance against the vampires that plague the world's survivors. In Season Two she journeys east towards a safe haven in Colorado and discovers her long lost sister who has been trained to kill vampires since birth.